Phenotypes Associated with This Genotype

Genotype
MGI:3761609

• Allelic Composition: Fas^lpr/Fas^lpr
• Genetic Background: MRL-Fas^lpr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased spleen weight ( J:126261 )

• mean weight is 0.9 grams

increased immunoglobulin level ( J:6257 )

• splenic cells in culture show four- to sixfold higher frequencies of spontaneous immunoglobulin release than controls

increased IgG level ( J:126261 )

• twice wild-type levels

increased IgM level ( J:126261 )

• about 1.7 fold higher than wild-type levels

abnormal T-helper 2 physiology ( J:6257 )

• enhanced T-helper cell activity is seen in vitro; removal of T cells from splenic cultures resulted in a significant reduction of the frequency of spontaneous immunoglobulin release in both autoimmune and normal spleen cell populations

• T cell-enriched populations from older animals provided twice the help offered by T cells of young syngeneic animals or T cells from young and older normal mice of the same H-2 haplotype

enlarged lymph nodes ( J:126261 )

• mean weight of axillary lymph nodes is 1.3 grams

increased anti-nuclear antigen antibody level ( J:126261 )

• levels are elevated compared to wild-type mice

increased anti-double stranded DNA antibody level ( J:126261 )

• 30 fold higher than in mice without autoimmune disease

glomerulonephritis ( J:126261 )

• lymphocyte infiltration, lobulation, and hyaline deposition noted in kidney

homeostasis/metabolism

increased blood urea nitrogen level ( J:126261 )

• mean levels are 52.4 mg/dl

hematopoietic system

increased spleen weight ( J:126261 )

• mean weight is 0.9 grams

increased immunoglobulin level ( J:6257 )

• splenic cells in culture show four- to sixfold higher frequencies of spontaneous immunoglobulin release than controls

increased IgG level ( J:126261 )

• twice wild-type levels

increased IgM level ( J:126261 )

• about 1.7 fold higher than wild-type levels

abnormal T-helper 2 physiology ( J:6257 )

• enhanced T-helper cell activity is seen in vitro; removal of T cells from splenic cultures resulted in a significant reduction of the frequency of spontaneous immunoglobulin release in both autoimmune and normal spleen cell populations

• T cell-enriched populations from older animals provided twice the help offered by T cells of young syngeneic animals or T cells from young and older normal mice of the same H-2 haplotype

cardiovascular system

vascular inflammation ( J:126261 )

• observed in kidneys with destruction of external elastic lamina common

renal/urinary system

glomerulonephritis ( J:126261 )

• lymphocyte infiltration, lobulation, and hyaline deposition noted in kidney

growth/size/body

increased spleen weight ( J:126261 )

• mean weight is 0.9 grams