Phenotypes Associated with This Genotype

Genotype
MGI:3760628

• Allelic Composition: Cd8a^tm1Asin/Cd8a^tm1Asin; Tg(CD2-TcraF5,CD2-TcrbF5)1Kio/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/10 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal positive T cell selection ( J:126026 )

• the conversion of double positive T cells into single-positive CD8 T cells is 20 fold greater than in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:126026 )

• these cells are almost absent in the thymus and the lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:126026 )

• the number of CD8-positive T cells that express the transgenic TCR is significantly higher compared to transgenic mice that have wild-type CD8 alleles

hematopoietic system

abnormal positive T cell selection ( J:126026 )

• the conversion of double positive T cells into single-positive CD8 T cells is 20 fold greater than in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:126026 )

• these cells are almost absent in the thymus and the lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:126026 )

• the number of CD8-positive T cells that express the transgenic TCR is significantly higher compared to transgenic mice that have wild-type CD8 alleles