Phenotypes Associated with This Genotype

Genotype
MGI:3760430

• Allelic Composition: Cd74^tm1Liz/Cd74^tm1Liz; H2-DMa^tm1Luc/H2-DMa^tm1Luc; Tg(CD74)AR194Ayr/?
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:88717 )

• the number of CD4+ T cells is reduced to levels below wild-type but similar to those observed in Cd74^tm1Liz H2-DMa^tm1Luc homozygotes

abnormal antigen presentation via MHC class II ( J:88717 )

• unlike in wild-type cells, splenocytes are unable to elicit presentation of MHC class II exogenous antigens or of two endogenous antigens (IgM and beta-2 microglobulin)

• however, Tg(CD74)AR194Ayr completely rescues the MHC class II peptide loading observed in Cd74^tm1Liz H2-DMa^tm1Luc homozygotes and presentation of endogenous antigens for CD22 is normal

• after incubation with Ealpha peptide, loading of MHC class II is less than on similarly treated Cd74^tm1Liz H2-DMa^tm1Luc Tg(CD74*)AR194Ayr splenocytes

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:88717 )

• the number of CD4+ T cells is reduced to levels below wild-type but similar to those observed in Cd74^tm1Liz H2-DMa^tm1Luc homozygotes