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Phenotypes Associated with This Genotype
Genotype
MGI:3759969
Allelic
Composition		 Gab1tm3Wbm/Gab1tm3Wbm
Mettm1Cbm/Met+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/cJ * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gab1tm3Wbm mutation (0 available); any Gab1 mutation (79 available)
Mettm1Cbm mutation (0 available); any Met mutation (81 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Cleft palate in Gab1tm3Wbm/Gab1tm3Wbm, Gab1tm2Wbm/Gab1tm2Wbm, Gab1tm1Wbm/Gab1tm1Wbm and Gab1tm3Wbm/Gab1tm3Wbm Mettm1Cbm/Met+ mice, but not in Gab1tm4Wbm/Gab1tm4Wbm mice

craniofacial
cleft secondary palate ( J:125303 )
• incidences of cleft palate are enhanced compared to in Gab1tm3Wbm homozygotes

digestive/alimentary system
cleft secondary palate ( J:125303 )
• incidences of cleft palate are enhanced compared to in Gab1tm3Wbm homozygotes

growth/size/body
cleft secondary palate ( J:125303 )
• incidences of cleft palate are enhanced compared to in Gab1tm3Wbm homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory