Phenotypes Associated with This Genotype

Genotype
MGI:3759780

• Allelic Composition: Il2^tm1Hor/Il2^tm1Hor; Tg(DO11.10)10Dlo/?
• Genetic Background: C.Cg-Il2^tm1Hor Tg(DO11.10)10Dlo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:88349 )

• the mean survival time is 4 months, which is significantly shorter than the average life expectancy of BALB/C mic

• however, the mean survival time is much longer than Il2 null mice on a BALB/c background that do not carry the TCR transgene

immune system

increased T cell proliferation ( J:88349 )

• when transferred into athymic mice, CD4 T cells continue to proliferate for up to three weeks in response to antigen

• CD 4 T cells from these transfer experiments also express high levels of activation markers

• However, when transferred with wild-type CD4-postive CD25-positive T cells, the mutant CD4 T cells stop proliferating between one to two weeks after antigen encounter

increased activated T cell number ( J:88349 )

• when transferred into athymic mice, there are 10-100 fold higher numbers of activated T cells three weeks after antigen

abnormal regulatory T cell physiology ( J:88349 )

• the abnormal proliferation of CD4 T cells upon transfer into athymic mice is reduced by the addition of wild-type CD4-postive CD25-positive T cells

• this suggests there is a defect in the regulatory T cell population in these mice

hematopoietic system

increased T cell proliferation ( J:88349 )

• when transferred into athymic mice, CD4 T cells continue to proliferate for up to three weeks in response to antigen

• CD 4 T cells from these transfer experiments also express high levels of activation markers

• However, when transferred with wild-type CD4-postive CD25-positive T cells, the mutant CD4 T cells stop proliferating between one to two weeks after antigen encounter

increased activated T cell number ( J:88349 )

• when transferred into athymic mice, there are 10-100 fold higher numbers of activated T cells three weeks after antigen

abnormal regulatory T cell physiology ( J:88349 )

• the abnormal proliferation of CD4 T cells upon transfer into athymic mice is reduced by the addition of wild-type CD4-postive CD25-positive T cells

• this suggests there is a defect in the regulatory T cell population in these mice

cellular

increased T cell proliferation ( J:88349 )

• when transferred into athymic mice, CD4 T cells continue to proliferate for up to three weeks in response to antigen

• CD 4 T cells from these transfer experiments also express high levels of activation markers

• However, when transferred with wild-type CD4-postive CD25-positive T cells, the mutant CD4 T cells stop proliferating between one to two weeks after antigen encounter