Mouse Genome Informatics
B6Brd.Cg-Tyrc-Brd Dp(11Cops3-Rnf112)1Jrl
phenotype observed in females
phenotype observed in males
N normal phenotype
• in an elevated plus maze
• mice exhibit decreased center to total distance ratio explored (0.26+/-0.01 compared to 0.33+/-0.04 in wild-type mice)
• mice exhibit impaired contextual conditioning (12.6+/-2.5% freezing to context compared to 36.0+/-6.5 in wild-type mice)
• mice exhibit decreased vertical activity (305+/-22 incidents compared to 499+/-60 incidences in wild-type mice)
• mice exhibit increased dominance compared with wild-type mice
• however, mice exhibit normal aggression
• 6.5 hours after introducing a paper towel to cages, only half of mice build nest compared with all wild-type mice
• mice exhibit impaired sociability and response to social novelty compared with wild-type mice
• only half of mice vocalize during handling compared with all wild-type mice

nervous system
• at 12 weeks

• at 12 weeks

adipose tissue

Mouse Models of Human Disease
Potocki-Lupski Syndrome; PTLS 610883 J:138598