Phenotypes Associated with This Genotype

Genotype
MGI:3758713

• Allelic Composition: Notch2^tm1Frad/Notch2^tm1Frad; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: BALB/c * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:125373 )

N • no ectopic B cell development in the thymus is observed after injection of mutant bone marrow progenitors into irradiated wild-type hosts

abnormal B cell differentiation ( J:125373 )

• hematopoietic stem cells do not develop in to B cells after 18 days in culture

absent marginal zone B cells ( J:125373 )

• loss of MZ B cells in spleen is detected

immune system

abnormal B cell differentiation ( J:125373 )

• hematopoietic stem cells do not develop in to B cells after 18 days in culture

absent marginal zone B cells ( J:125373 )

• loss of MZ B cells in spleen is detected