Phenotypes Associated with This Genotype

Genotype
MGI:3758692

• Allelic Composition: Dp(11Cops3-Rnf112)1Jrl/0
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased abdominal fat pad weight ( J:83302 )

• abdominal fat pad weight is reduced (0.30+/-0.06 g compared to 0.56+/-0.05 g in wild-type mice)

decreased percent body fat/body weight ( J:83302 )

• 1.2% compared to 2% in wild-type mice

growth/size/body

decreased body weight ( J:83302 )

• mice weigh less than wild-type mice in the first month after birth and the difference in body weight persists for throughout their lifespan

hematopoietic system

decreased spleen weight ( J:83302 )

• 0.056+/-0.006 g compared to 0.070+/-0.004 g in wild-type mice

behavior/neurological

abnormal behavior ( J:88027 )

• self-injury behavior is observed

• however, no self-injury behavior is observed when mice are single housed

abnormal contextual conditioning behavior ( J:88027 )

• male mice, but not female mice, display less freezing following contextual conditioning

abnormal anxiety-related response ( J:88027 )

• male mice, but not female mice, exhibit fewer light-dark transitions compared to wild-type mice in a light-dark test

decreased startle reflex ( J:88027 )

• mice startle less than wild-type mice

hyperactivity ( J:88027 )

• mice spend more time moving than wild-type mice

increased locomotor activity ( J:88027 )

♂ • male mice, but not female mice, travel further and spend more time moving than wild-type mice

nervous system

nervous system phenotype ( J:83302 )

N • no evidence of epileptic seizures are detected

reproductive system

reproductive system phenotype ( J:83302 )

N • mice have normal fertility

vision/eye

vision/eye phenotype ( J:83302 )

N • mice have normal eye development

immune system

decreased spleen weight ( J:83302 )

• 0.056+/-0.006 g compared to 0.070+/-0.004 g in wild-type mice