Phenotypes Associated with This Genotype

Genotype
MGI:3758176

• Allelic Composition: Tg(Th-SNCA*A30P*A53T)39Eric/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal righting response ( J:76482 )

• 2-3 month-old mice have shorter time to right than wild-type

• with age, righting time increases significantly compared to young transgenic mice; controls do not show significant differences with age

abnormal locomotor activation ( J:76482 )

• with age (at 7-9 and 16-18 months), mice have undergone a progressive decline in locomotor activity

hyperactivity ( J:76482 )

• 2-3 month-old mice are more active relative to wild-type

nervous system

abnormal dopaminergic neuron morphology ( J:76482 )

• neurons in median forebrain bundle are more beaded and dilated in appearance compared to controls in young (2-3 months) mice

• terminals of neurons in the nucleus accumbens are abnormal with small caliber processes and dilated or enlarged terminals

homeostasis/metabolism

decreased dopamine level ( J:76482 )

• dopamine levels are lower in transgenic brains than in control brains; in aged mice, levels are signicantly lower than in 2-3 month-old transgenic mice

• similar results are seen for dopamine metabolites like DOPAC and homovanillic acid