Analysis Tools
nervous system
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• MPTP-treated mice exhibit decreased microglial cells with longer processes compared with similarly treated wild-type mice
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• neuronal cell death in MPTP-treated homozygotes is comparable to sham-treated wildtype and significantly less than MPTP-treated wildtype, suggesting a protective effect
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• MPTP-treated homozygotes exhibit an increase in the number of microglial cells, however, MPTP-treated wildtype mice exhibited a greater increase
• numbers of GFAP-positive astrocytes increased in the MPTP-treated wildtype mice, but not in MPTP-treated homozygotes or sham-treated wildtype mice
• astrocytic processes are longer in MPTP-treated homozygotes than in both MPTP-treated wildtype and sham-treated wildtype mice
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• tyrosine hydroxylase (TH) positive nerve fibers in the striatum are decreased to a lesser extent in MPTP-treated homozygotes than in MPTP-treated wildtype mice
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• MPTP-treated mice exhibit increased neuron and TH+ fiber survival compared to in similarly treated wild-type mice
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immune system
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• MPTP-treated mice exhibit decreased microglial cells with longer processes compared with similarly treated wild-type mice
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• mice exhibit decreased incidence of experimental autoimmune uveoretinitis with fewer infiltrating inflammatory cells in the vitreous, decreased granulomas, and reduced lymphocyte proliferation compared with similarly treated wild-type mice
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• mice exhibit decreased granulomas in a model of experimental autoimmune uveoretinitis compared with similarly treated wild-type mice
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hematopoietic system
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• MPTP-treated mice exhibit decreased microglial cells with longer processes compared with similarly treated wild-type mice
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homeostasis/metabolism
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• MPTP-treated mice exhibit increased neuron and TH+ fiber survival and decreased microglial cells with longer processes compared with similarly treated wild-type mice
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• neuronal cell death in MPTP-treated homozygotes is comparable to sham-treated wildtype and significantly less than MPTP-treated wildtype, suggesting a protective effect
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cellular
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• MPTP-treated mice exhibit decreased microglial cells with longer processes compared with similarly treated wild-type mice
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• neuronal cell death in MPTP-treated homozygotes is comparable to sham-treated wildtype and significantly less than MPTP-treated wildtype, suggesting a protective effect
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