About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3757977
Allelic
Composition
Tg(Myh6-tTA)55Rbns/0
Tg(Myh6/tetO-Gsk3b*S9A)1Rbns/0
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Myh6/tetO-Gsk3b*S9A)1Rbns mutation (0 available)
Tg(Myh6-tTA)55Rbns mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• the normal hypertrophic response to transaortic coarctation (TAC) is blunted in double transgenics in the absence of Dox; when transgenics are kept on Dox and Gsk3b expression is suppressed, they develop hypertrophy comparable to that of controls

homeostasis/metabolism
• the normal hypertrophic response to transaortic coarctation (TAC) is blunted in double transgenics in the absence of Dox; when transgenics are kept on Dox and Gsk3b expression is suppressed, they develop hypertrophy comparable to that of controls


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/18/2025
MGI 6.24
The Jackson Laboratory