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Phenotypes Associated with This Genotype
Genotype
MGI:3757843
Allelic
Composition
Tg(Th-SNCA*)1702Yosh/0
Genetic
Background
involves: C3H * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Th-SNCA*)1702Yosh mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• both diurnal and nocturnal spontaneous locomotor activities are reduced compared to controls; significant recovery is seen upon injection of 150 mg/kg of dopamine precursor L-DOPA, whereas this dose does not affect non-transgenic controls (J:125149)
• both diurnal and nocturnal spontaneous locomotor activities are reduced compared to controls; significant recovery is seen upon injection of 150 mg/kg of dopamine precursor L-DOPA, whereas this dose does not affect non-transgenic controls (J:125149)

nervous system
• striatal dopamine, DA, and the dopamine metabolite homovanillic acid, HVA are reduced to ~49% and ~52% relative to controls; content of another metabolite, DOPAC, is reduced similarly in 8 week old mice (J:125149)
• striatal dopamine, DA, and the dopamine metabolite homovanillic acid, HVA are reduced to ~49% and ~52% relative to controls; content of another metabolite, DOPAC, is reduced similarly in 8 week old mice (J:125149)
• ~45% of dopaminergic neurons in the substantia nigra pars compacta, SNc, with the lateral part particularly affected, compared to non-transgenic littermates at 8 weeks of age or in transgnic mice expressing full-length mutant alpha-synuclein; considerable loss of neuronal cell bodies in the SNc region is observed (J:125149)
• no loss is observed in the ventral tegmental area, VTA (J:125149)
• loss is stable and no increased loss is seen to 52 weeks of age (J:125149)
• ~45% of dopaminergic neurons in the substantia nigra pars compacta, SNc, with the lateral part particularly affected, compared to non-transgenic littermates at 8 weeks of age or in transgnic mice expressing full-length mutant alpha-synuclein; considerable loss of neuronal cell bodies in the SNc region is observed (J:125149)
• no loss is observed in the ventral tegmental area, VTA (J:125149)
• loss is stable and no increased loss is seen to 52 weeks of age (J:125149)
• tyrosine hydroxylase-positive, TH+, neurites are markedly impaired in striatum of mutants (J:125149)
• tyrosine hydroxylase-positive, TH+, neurites are markedly impaired in striatum of mutants (J:125149)

homeostasis/metabolism
• striatal dopamine, DA, and the dopamine metabolite homovanillic acid, HVA are reduced to ~49% and ~52% relative to controls; content of another metabolite, DOPAC, is reduced similarly in 8 week old mice (J:125149)
• striatal dopamine, DA, and the dopamine metabolite homovanillic acid, HVA are reduced to ~49% and ~52% relative to controls; content of another metabolite, DOPAC, is reduced similarly in 8 week old mice (J:125149)

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:125149


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory