Mouse Genome Informatics
tg
    Tg(Th-SNCA*)1702Yosh/0
involves: C3H * C57BL/6J
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• both diurnal and nocturnal spontaneous locomotor activities are reduced compared to controls; significant recovery is seen upon injection of 150 mg/kg of dopamine precursor L-DOPA, whereas this dose does not affect non-transgenic controls

nervous system
• striatal dopamine, DA, and the dopamine metabolite homovanillic acid, HVA are reduced to ~49% and ~52% relative to controls; content of another metabolite, DOPAC, is reduced similarly in 8 week old mice
• ~45% of dopaminergic neurons in the substantia nigra pars compacta, SNc, with the lateral part particularly affected, compared to non-transgenic littermates at 8 weeks of age or in transgnic mice expressing full-length mutant alpha-synuclein; considerable loss of neuronal cell bodies in the SNc region is observed
• no loss is observed in the ventral tegmental area, VTA
• loss is stable and no increased loss is seen to 52 weeks of age
• tyrosine hydroxylase-positive, TH+, neurites are markedly impaired in striatum of mutants

homeostasis/metabolism
• striatal dopamine, DA, and the dopamine metabolite homovanillic acid, HVA are reduced to ~49% and ~52% relative to controls; content of another metabolite, DOPAC, is reduced similarly in 8 week old mice

Mouse Models of Human Disease
OMIM IDRef(s)
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:125149