Phenotypes Associated with This Genotype

Genotype
MGI:3757691

• Allelic Composition: Slc27a5^tm1Asta/Slc27a5^tm1Asta
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating glucose level ( J:124917 )

• 114+/-11.6 mg/dL compared to 92+/-12.8 mg/dL in wild-type mice

increased circulating insulin level ( J:124917 )

• 0.95+/-0.13 ng/mL compared to 0.76+/-0.15 ng/mL in wild-type mice

abnormal lipid homeostasis ( J:124917 )

• postprandial clearance of free fatty acids and triglycerides is impaired

• postprandial dietary fats are redistributed away from the liver to other tissues such as skeletal and cardiac muscles and adipose tissue

• after a 12-week high-fat diet challenge, 60% of caloric fat content is redistributed away from the liver to other organs

decreased circulating ketone body level ( J:124917 )

• in a fasting state, ketone output is decreased

abnormal lipid level ( J:124917 )

• the degree of reduction in lipid levels in the liver is similar to decreases in long chain fatty acid uptake by hepatocytes

decreased circulating cholesterol level ( J:124917 )

• 4.8+/-1.5 mmol/L compared to 7.5+/-1.3 mmol/L in wild-type mice

decreased circulating triglyceride level ( J:124917 )

• 104+/-7.36 mg/dL compared to 126+/-12.8 mg/dL in wild-type mice

decreased liver cholesterol level ( J:124917 )

• the amount of cholesterol esters in the liver are decreased relative to in wild-type mice

decreased fatty acids level ( J:124917 )

• total fatty acid levels in the liver are decreased by 37% compared to in wild-type livers

decreased circulating free fatty acids level ( J:124917 )

• 1.39+/-0.03 nmol/L compared to 1.59+/-0.07 nmol/L in wild-type mice

decreased saturated fatty acids level ( J:124917 )

• saturated fatty acid levels in the liver are decreased by 62% compared to in wild-type livers

decreased unsaturated fatty acids level ( J:124917 )

• poly- and monounsaturated fatty acid levels in the liver are decreased by 60% and 55%, respectively, compared to in wild-type livers

decreased liver triglyceride level ( J:124917 )

• di- and triglyceride levels in the liver are reduced by 48% compared to in wild-type livers

• triglyceride levels in the liver are reduced by 59% compared to in wild-type livers

liver/biliary system

decreased liver cholesterol level ( J:124917 )

• the amount of cholesterol esters in the liver are decreased relative to in wild-type mice

decreased liver triglyceride level ( J:124917 )

• di- and triglyceride levels in the liver are reduced by 48% compared to in wild-type livers

• triglyceride levels in the liver are reduced by 59% compared to in wild-type livers

abnormal hepatocyte morphology ( J:124917 )

• as determined by FACS analysis, hepatocyte size is increased while cellular granulosity is decreased relative to wild-type hepatocytes

• hepatocytes exhibit hypertrophy (average hepatocyte diameter of 18.7 um compared to 15.1 um in wild-type hepatocytes)

• the abundance of intracellular lipid droplets is decreased (190 compared to 271 in wild-type mice)

abnormal liver physiology ( J:124917 )

• long chain fatty acid uptake by hepatocytes is decreased by greater than 40%

• the degree of reduction in lipid levels in the liver is similar to decreases in long chain fatty acid uptake by hepatocytes

• fatty acid synthesis in the liver is increased relative to in wild-type livers

• in a fasting state, liver triglyceride output is decreased relative to in wild-type livers