Phenotypes Associated with This Genotype

Genotype
MGI:3757647

• Allelic Composition: Gdnf^tm1Rosl/Gdnf^tm1Rosl
• Genetic Background: involves: 129S2/SvPas * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal innervation pattern to muscle ( J:78718 )

• nerves to the cutaneous maximus and latissimus dorsi are missing or with reduced numbers of fibers by E11.5 to E12.5

abnormal spinal nerve morphology ( J:78718 )

• caudal nerve branches from the brachial plexus to the cutaneous maximus and latissimus dorsi become atrophied and misrouted by E11

abnormal spinal cord lateral motor column morphology ( J:78718 )

• reduced numbers of motor neurons expressing Pea3 in the lateral motor colomn of segments C5 to C8 of the spinal cord at E12.5