Phenotypes Associated with This Genotype

Genotype
MGI:3723641

• Allelic Composition: Pax9^tm1.1Hpt/Pax9^tm1.1Hpt; H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:125026 )

• mice die at birth

craniofacial

absent alveolar process ( J:125026 )

arrest of tooth development ( J:125026 )

• tooth development is arrested at the bud stage

absent teeth ( J:125026 )

absent mandibular coronoid process ( J:125026 )

abnormal maxillary shelf morphology ( J:125026 )

• the palatal processes of the maxilla is displaced laterally

absent premaxilla ( J:125026 )

abnormal palatine bone horizontal plate morphology ( J:125026 )

• the palatal processes of the palatine is displaced laterally

cleft secondary palate ( J:125026 )

failure of palatal shelf elevation ( J:125026 )

behavior/neurological

aphagia ( J:125026 )

• mice die with no evidence of feeding

digestive/alimentary system

abnormal maxillary shelf morphology ( J:125026 )

• the palatal processes of the maxilla is displaced laterally

abnormal palatine bone horizontal plate morphology ( J:125026 )

• the palatal processes of the palatine is displaced laterally

cleft secondary palate ( J:125026 )

failure of palatal shelf elevation ( J:125026 )

skeleton

absent alveolar process ( J:125026 )

arrest of tooth development ( J:125026 )

• tooth development is arrested at the bud stage

absent teeth ( J:125026 )

absent mandibular coronoid process ( J:125026 )

abnormal maxillary shelf morphology ( J:125026 )

• the palatal processes of the maxilla is displaced laterally

absent premaxilla ( J:125026 )

abnormal palatine bone horizontal plate morphology ( J:125026 )

• the palatal processes of the palatine is displaced laterally

growth/size/body

absent alveolar process ( J:125026 )

arrest of tooth development ( J:125026 )

• tooth development is arrested at the bud stage

absent teeth ( J:125026 )

absent mandibular coronoid process ( J:125026 )

abnormal maxillary shelf morphology ( J:125026 )

• the palatal processes of the maxilla is displaced laterally

absent premaxilla ( J:125026 )

abnormal palatine bone horizontal plate morphology ( J:125026 )

• the palatal processes of the palatine is displaced laterally

cleft secondary palate ( J:125026 )

failure of palatal shelf elevation ( J:125026 )