Phenotypes for H2az2 Pax9 MGI:3723641 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pax9^tm1.1Hpt/Pax9^tm1.1Hpt H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S2/SvPas * C57BL/6 * CBA * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)
Pax9^tm1.1Hpt mutation (0 available); any Pax9 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:125026 )

• mice die at birth

craniofacial

absent alveolar process ( J:125026 )

arrest of tooth development ( J:125026 )

• tooth development is arrested at the bud stage

absent teeth ( J:125026 )

absent mandibular coronoid process ( J:125026 )

abnormal maxillary shelf morphology ( J:125026 )

• the palatal processes of the maxilla is displaced laterally

absent premaxilla ( J:125026 )

abnormal palatine bone horizontal plate morphology ( J:125026 )

• the palatal processes of the palatine is displaced laterally

cleft secondary palate ( J:125026 )

failure of palatal shelf elevation ( J:125026 )

behavior/neurological

aphagia ( J:125026 )

• mice die with no evidence of feeding

digestive/alimentary system

abnormal maxillary shelf morphology ( J:125026 )

• the palatal processes of the maxilla is displaced laterally

abnormal palatine bone horizontal plate morphology ( J:125026 )

• the palatal processes of the palatine is displaced laterally

cleft secondary palate ( J:125026 )

failure of palatal shelf elevation ( J:125026 )

skeleton

absent alveolar process ( J:125026 )

arrest of tooth development ( J:125026 )

• tooth development is arrested at the bud stage

absent teeth ( J:125026 )

absent mandibular coronoid process ( J:125026 )

abnormal maxillary shelf morphology ( J:125026 )

• the palatal processes of the maxilla is displaced laterally

absent premaxilla ( J:125026 )

abnormal palatine bone horizontal plate morphology ( J:125026 )

• the palatal processes of the palatine is displaced laterally

growth/size/body

absent alveolar process ( J:125026 )

arrest of tooth development ( J:125026 )

• tooth development is arrested at the bud stage

absent teeth ( J:125026 )

abnormal maxillary shelf morphology ( J:125026 )

• the palatal processes of the maxilla is displaced laterally

abnormal palatine bone horizontal plate morphology ( J:125026 )

• the palatal processes of the palatine is displaced laterally

cleft secondary palate ( J:125026 )

failure of palatal shelf elevation ( J:125026 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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