Phenotypes Associated with This Genotype

Genotype
MGI:3723582

• Allelic Composition: Cd38^tm1Lnd/Cd38^tm1Lnd
• Genetic Background: B6.129P2-Cd38^tm1Lnd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

increased pancreatic islet cell apoptosis ( J:116576 )

• islets are significantly more susceptible to apoptosis at physiological glucose concentrations, in the presences of palmitate, or in the absence of serum

decreased pancreatic beta cell mass ( J:116576 )

• small but significant decrease in beta cell mass is observed under normal diet and high-fat feeding relative to controls

disorganized pancreatic islets ( J:116576 )

• disrupted islet architecture is observed

• glucagon-containing alpha cells are distributed diffusely between beta cells, whereas in wild-type islets, alpha cells are exclusively in the islet mantle

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:116576 )

N • blood glucose is not significantly different from wild-type regardless of diet

N • glucose tolerance does not differ significantly, but there is a trend toward higher 30-minute glucose values in female mutants on both normal and high-fat diets

N • insulin tolerance is similar to wild-type on both normal and high-fat diets

insulin resistance ( J:116576 )

• significant insulin resistance is observed in mice fed a high-fat diet

cellular

increased pancreatic islet cell apoptosis ( J:116576 )

• islets are significantly more susceptible to apoptosis at physiological glucose concentrations, in the presences of palmitate, or in the absence of serum