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Phenotypes Associated with This Genotype
Genotype
MGI:3723353
Allelic
Composition		 Plectm2Gwi/Plectm4Gwi
Tg(Krt1-5-cre/ERT)1Ipc/?
Genetic
Background		 involves: 129 * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plectm2Gwi mutation (0 available); any Plec mutation (174 available)
Plectm4Gwi mutation (0 available); any Plec mutation (174 available)
Tg(Krt1-5-cre/ERT)1Ipc mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
impaired skin barrier function ( J:124213 )
• following treatment with tamoxifen and tape stripping (10 times), mice exhibit increased transepidermal water loss not observed in control Plec1tm4Gwi homozygotes

integument
impaired skin barrier function ( J:124213 )
• following treatment with tamoxifen and tape stripping (10 times), mice exhibit increased transepidermal water loss not observed in control Plec1tm4Gwi homozygotes
blistering ( J:124213 )
• following treatment with tamoxifen and tape stripping (10 times), mice develop small blisters
abnormal skin condition ( J:124213 )
• skin around lesions induced by treatment with tamoxifen and tape stripping (10 times) is more fragile

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory