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Phenotypes Associated with This Genotype
Genotype
MGI:3722298
Allelic
Composition		 Ppargtm1.1Gonz/Ppargtm1.1Gonz
Tg(Mx1-cre)1Cgn/?
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm1.1Gonz mutation (0 available); any Pparg mutation (42 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:75777 )
• basal cholesterol efflux from cholesterol-loaded macrophages to HDL is reduced

hematopoietic system
abnormal macrophage physiology ( J:75777 )
• basal cholesterol efflux from cholesterol-loaded macrophages to HDL is reduced

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory