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Phenotypes Associated with This Genotype
Genotype
MGI:3721945
Allelic
Composition
Evctm1Jago/Evctm1Jago
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Evctm1Jago mutation (0 available); any Evc mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• half of mice born are dead by day 2
• mice survive to adulthood if fed soft, well-hydrated food

reproductive system
• mice do not breed

skeleton
• the margin between the bone and cartilage at the basioccipital junction is irregular
• teeth anomalies include absence of upper incisor or a single incisor
• the first molar is frequently smaller
• the upper end of the tibia is abnormally shaped
• embryonic growth plates have shorter proliferative and hypertrophic chondrocyte layers
• shortening of the radius and ulna are more pronounced than shortening of the femur and tibia
• at P18
• at P1 and P18
• at P1 and P18
• at P1 and P18
• at P1 and P18
• the margin between the bone and cartilage at the costochondral junction is irregular
• at P1 and P18
• the rib cage is narrow than in wild-type mice
• the rib cage is narrow and smaller than in wild-type mice
• premature mineralization of some of the pedicles between the vertebral bodies and vertebral laminae occurs
• chondrocytes differentiate from columnar to hypertrophic occurs prematurely
• there is a delay in the formation of the periosteum adjacent to the prehypertrophic and hypertrophic chondrocytes
• secondary ossification centers is delayed

growth/size/body
• teeth anomalies include absence of upper incisor or a single incisor
• the first molar is frequently smaller
• mice are smaller in size than wild-type mice

behavior/neurological
• mice do not eat normal food

limbs/digits/tail
• at P18
• at P1 and P18
• at P1 and P18
• at P1 and P18
• the upper end of the tibia is abnormally shaped
• at P1 and P18

craniofacial
• the margin between the bone and cartilage at the basioccipital junction is irregular
• teeth anomalies include absence of upper incisor or a single incisor
• the first molar is frequently smaller

Mouse Models of Human Disease
OMIM ID Ref(s)
Ellis-Van Creveld Syndrome; EVC 225500 J:124105


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory