Mouse Genome Informatics
hm
    Evctm1Jago/Evctm1Jago
involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• half of mice born are dead by day 2
• mice survive to adulthood if fed soft, well-hydrated food

reproductive system
• mice do not breed

skeleton
• the margin between the bone and cartilage at the basioccipital junction is irregular
• the upper end of the tibia is abnormally shaped
• embryonic growth plates have shorter proliferative and hypertrophic chondrocyte layers
• shortening of the radius and ulna are more pronounced than shortening of the femur and tibia
• at P18
• at P1 and P18
• at P1 and P18
• at P1 and P18
• at P1 and P18
• the margin between the bone and cartilage at the costochondral junction is irregular
• at P1 and P18
• the rib cage is narrow than in wild-type mice
• the rib cage is narrow and smaller than in wild-type mice
• premature mineralization of some of the pedicles between the vertebral bodies and vertebral laminae occurs
• chondrocytes differentiate from columnar to hypertrophic occurs prematurely
• there is a delay in the formation of the periosteum adjacent to the prehypertrophic and hypertrophic chondrocytes
• secondary ossification centers is delayed

growth/size
• teeth anomalies include absence of upper incisor or a single incisor
• the first molar is frequently smaller
• mice are smaller in size than wild-type mice

behavior/neurological
• mice do not eat normal food

limbs/digits/tail
• at P18
• at P1 and P18
• at P1 and P18
• at P1 and P18
• the upper end of the tibia is abnormally shaped
• at P1 and P18

craniofacial
• the margin between the bone and cartilage at the basioccipital junction is irregular
• teeth anomalies include absence of upper incisor or a single incisor
• the first molar is frequently smaller

Mouse Models of Human Disease
OMIM IDRef(s)
Ellis-Van Creveld Syndrome; EVC 225500 J:124105