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Phenotypes Associated with This Genotype
Genotype
MGI:3721945
Allelic
Composition
Evctm1Jago/Evctm1Jago
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Evctm1Jago mutation (0 available); any Evc mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• half of mice born are dead by day 2 (J:124105)
• mice survive to adulthood if fed soft, well-hydrated food (J:124105)
• half of mice born are dead by day 2 (J:124105)
• mice survive to adulthood if fed soft, well-hydrated food (J:124105)

reproductive system
• mice do not breed (J:124105)
• mice do not breed (J:124105)

skeleton
• the margin between the bone and cartilage at the basioccipital junction is irregular (J:124105)
• the margin between the bone and cartilage at the basioccipital junction is irregular (J:124105)
• the upper end of the tibia is abnormally shaped (J:124105)
• the upper end of the tibia is abnormally shaped (J:124105)
• embryonic growth plates have shorter proliferative and hypertrophic chondrocyte layers (J:124105)
• embryonic growth plates have shorter proliferative and hypertrophic chondrocyte layers (J:124105)
• shortening of the radius and ulna are more pronounced than shortening of the femur and tibia (J:124105)
• shortening of the radius and ulna are more pronounced than shortening of the femur and tibia (J:124105)
• at P18 (J:124105)
• at P18 (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)
• the margin between the bone and cartilage at the costochondral junction is irregular (J:124105)
• the margin between the bone and cartilage at the costochondral junction is irregular (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)
• the rib cage is narrow than in wild-type mice (J:124105)
• the rib cage is narrow than in wild-type mice (J:124105)
• the rib cage is narrow and smaller than in wild-type mice (J:124105)
• the rib cage is narrow and smaller than in wild-type mice (J:124105)
• premature mineralization of some of the pedicles between the vertebral bodies and vertebral laminae occurs (J:124105)
• premature mineralization of some of the pedicles between the vertebral bodies and vertebral laminae occurs (J:124105)
• chondrocytes differentiate from columnar to hypertrophic occurs prematurely (J:124105)
• chondrocytes differentiate from columnar to hypertrophic occurs prematurely (J:124105)
• there is a delay in the formation of the periosteum adjacent to the prehypertrophic and hypertrophic chondrocytes (J:124105)
• secondary ossification centers is delayed (J:124105)
• there is a delay in the formation of the periosteum adjacent to the prehypertrophic and hypertrophic chondrocytes (J:124105)
• secondary ossification centers is delayed (J:124105)

growth/size/body
• teeth anomalies include absence of upper incisor or a single incisor (J:124105)
• teeth anomalies include absence of upper incisor or a single incisor (J:124105)
• the first molar is frequently smaller (J:124105)
• the first molar is frequently smaller (J:124105)
• mice are smaller in size than wild-type mice (J:124105)
• mice are smaller in size than wild-type mice (J:124105)
• at P18 (J:124105)
• at P18 (J:124105)

behavior/neurological
• mice do not eat normal food (J:124105)
• mice do not eat normal food (J:124105)

limbs/digits/tail
• at P18 (J:124105)
• at P18 (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)
• the upper end of the tibia is abnormally shaped (J:124105)
• the upper end of the tibia is abnormally shaped (J:124105)
• at P1 and P18 (J:124105)
• at P1 and P18 (J:124105)

craniofacial
• the margin between the bone and cartilage at the basioccipital junction is irregular (J:124105)
• the margin between the bone and cartilage at the basioccipital junction is irregular (J:124105)
• teeth anomalies include absence of upper incisor or a single incisor (J:124105)
• teeth anomalies include absence of upper incisor or a single incisor (J:124105)
• the first molar is frequently smaller (J:124105)
• the first molar is frequently smaller (J:124105)

Mouse Models of Human Disease
OMIM ID Ref(s)
Ellis-Van Creveld Syndrome; EVC 225500 J:124105


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory