About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3721945
Allelic
Composition
Evctm1Jago/Evctm1Jago
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Evctm1Jago mutation (0 available); any Evc mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• half of mice born are dead by day 2
• mice survive to adulthood if fed soft, well-hydrated food

reproductive system
• mice do not breed

skeleton
• the margin between the bone and cartilage at the basioccipital junction is irregular
• teeth anomalies include absence of upper incisor or a single incisor
• the first molar is frequently smaller
• the upper end of the tibia is abnormally shaped
• embryonic growth plates have shorter proliferative and hypertrophic chondrocyte layers
• shortening of the radius and ulna are more pronounced than shortening of the femur and tibia
• at P18
• at P1 and P18
• at P1 and P18
• at P1 and P18
• at P1 and P18
• the margin between the bone and cartilage at the costochondral junction is irregular
• at P1 and P18
• the rib cage is narrow than in wild-type mice
• the rib cage is narrow and smaller than in wild-type mice
• premature mineralization of some of the pedicles between the vertebral bodies and vertebral laminae occurs
• chondrocytes differentiate from columnar to hypertrophic occurs prematurely
• there is a delay in the formation of the periosteum adjacent to the prehypertrophic and hypertrophic chondrocytes
• secondary ossification centers is delayed

growth/size/body
• teeth anomalies include absence of upper incisor or a single incisor
• the first molar is frequently smaller
• mice are smaller in size than wild-type mice

behavior/neurological
• mice do not eat normal food

limbs/digits/tail
• at P18
• at P1 and P18
• at P1 and P18
• at P1 and P18
• the upper end of the tibia is abnormally shaped
• at P1 and P18

craniofacial
• the margin between the bone and cartilage at the basioccipital junction is irregular
• teeth anomalies include absence of upper incisor or a single incisor
• the first molar is frequently smaller

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Ellis-Van Creveld syndrome DOID:12714 OMIM:225500
J:124105


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory