Phenotypes Associated with This Genotype

Genotype
MGI:3721540

• Allelic Composition: Del(11Cxcl16-Zmynd15)1Ifc/Del(11Cxcl16-Zmynd15)1Ifc; Ldlr^tm1Her/Ldlr^tm1Her
• Genetic Background: B6.129S-Ldlr^tm1Her Del(11Cxcl16-Zmynd15)1Ifc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

atherosclerotic lesions ( J:123851 )

• after 6 weeks, atherosclerosis lesions are 46% larger than in Ldlr^tm1Her homozygotes

• after 10 weeks, atherosclerosis lesions are 27% and 56% (when assessed with serial sections of the aortic root stained with oil red O) larger than in Ldlr^tm1Her homozygotes

• atherosclerotic lesions contain 80% more apoptotic cells than in Ldlr^tm1Her homozygotes

cellular

increased apoptosis ( J:123851 )

• atherosclerotic lesions contain 80% more apoptotic cells than in Ldlr^tm1Her homozygotes