Phenotypes Associated with This Genotype

Genotype
MGI:3721440

• Allelic Composition: Cdk5r1^tm1Lht/Cdk5r1⁺; Cdk5r2^tm1Lht/Cdk5r2^tm1Lht
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal neuron differentiation ( J:71181 )

• obliquely oriented clumps of neurons are more prominent in cerebral walls than in Cdk5r1-null mice

abnormal cortical marginal zone morphology ( J:71181 )

• marginal zone is obscured

thin cortical plate ( J:71181 )

abnormal hippocampus layer morphology ( J:71181 )

• lamination defects are observed

abnormal cerebellum morphology ( J:71181 )

• fissura secuda is less prominent than in wild-type or single-mutant cerebella at E18.5

small cerebellum ( J:71181 )

• decreased size relative to wild-type or single-null mice at E18.5

cellular

abnormal neuron differentiation ( J:71181 )

• obliquely oriented clumps of neurons are more prominent in cerebral walls than in Cdk5r1-null mice