Phenotypes Associated with This Genotype

Genotype
MGI:3721134

• Allelic Composition: Atf2^tm2Nicj/Atf2^tm2Nicj; Atf7^tm1Nicj/Atf7^tm1Nicj
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:123909 )

• pups die between E11.5 and E12.5

liver/biliary system

increased hepatocyte apoptosis ( J:123909 )

• at E11.5, a large increase in apoptotic liver cells is observed

abnormal liver morphology ( J:123909 )

• some pups recovered between E11.5 and E12.5 exhibit defects in liver architecture

• normal sized livers have severe tissue loss accompanied by expansion of sinuses

• a moderate decrease in proliferating liver cells and a large increase in apoptotic liver cells are observed even prior to reduction in liver size

• fewer erythropoeitic (Ter119+) cells are found due to increased apoptosis

liver hypoplasia ( J:123909 )

• some pups recovered between E11.5 and E12.5 exhibit liver hypoplasia

hematopoietic system

abnormal common myeloid progenitor cell morphology ( J:123909 )

• E12.5 myeloid and erythroid precursors from the liver form fewer hematopoeitic colonies compared to wild-type cells

anemia ( J:123909 )

• some pups recovered between E11.5 and E12.5 are anemic

cardiovascular system

heart hypoplasia ( J:123909 )

• some pups recovered between E11.5 and E12.5 exhibit heart hypoplasia with pericardial hemorrhages

hemopericardium ( J:123909 )

• some pups recovered between E11.5 and E12.5 exhibit heart hypoplasia with pericardial hemorrhages

embryo

embryonic growth arrest ( J:123909 )

• some pups recovered between E11.5 and E12.5 exhibit developmental arrest and death

embryonic growth retardation ( J:123909 )

• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation

cellular

increased apoptosis ( J:123909 )

• hepatocytes and hematopoeitic cells of the liver undergo increased amounts of apoptosis

• explanted fetal liver cells grown in culture barely increase in cell number whereas wild-type cells double every 24 hours due to an increase in apoptosis

increased hepatocyte apoptosis ( J:123909 )

• at E11.5, a large increase in apoptotic liver cells is observed

decreased cell proliferation ( J:123909 )

• explanted fetal liver cells grown in culture barely increase in cell number whereas wild-type cells double every 24 hours due to an increase in apoptosis

growth/size/body

embryonic growth retardation ( J:123909 )

• some pups recovered between E11.5 and E12.5 exhibit developmental growth retardation

homeostasis/metabolism

hemopericardium ( J:123909 )

• some pups recovered between E11.5 and E12.5 exhibit heart hypoplasia with pericardial hemorrhages