Atf2^tm2Nicj
Targeted Allele Detail

Summary

• Symbol: Atf2^tm2Nicj
• Name: activating transcription factor 2; targeted mutation 2, Nic Jones
• MGI ID: MGI:3720851
• Synonyms: Atf2^AA
• Gene: Atf2 Location: Chr2:73646853-73722983 bp, - strand Genetic Position: Chr2, 43.86 cM
• Alliance: Atf2^tm2Nicj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123909
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Nucleotide substitutions
• Mutation details: A targeting vector was designed to mutate Thr51 and Thr53 into alanines in exon 4 (T51A, T53A). A floxed neo was inserted into intron 3. (J:123909)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atf2 Mutation: 89 strains or lines available

References

• Original: J:123909 Breitwieser W, et al., Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells. Genes Dev. 2007 Aug 15;21(16):2069-82
• All: 2 reference(s)