Phenotypes Associated with This Genotype

Genotype
MGI:3721063

• Allelic Composition: Rr349^tm1Wgw/Rr349^tm1Wgw
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:80121 )

• homozygotes died between 13.5 and 15.5 days

hematopoietic system

anemia ( J:80121 )

• severe anemia in dyeing fetuses

abnormal erythrocyte morphology ( J:80121 )

• 14.5 days fetal blood showed marked dyserythropoiesis and an increased portion of yolk sac erythroid cells

abnormal hemoglobin ( J:80121 )

• ratio of alpha-globin RNA to beta-globin RNA was reduced

liver/biliary system

abnormal liver development ( J:80121 )

• reduced fetal liver size with considerable dyserythropoiesis

integument

pallor ( J:80121 )

• homozygous fetuses were recognizable from their obvious pallor