Phenotypes Associated with This Genotype

Genotype
MGI:3720816

• Allelic Composition: Plg^tm1Dco/Plg^tm1Dco
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, no fibrinolysis activity is observed (2.3%+/-1.1% lysis compared to 47.6%+/-8.9% in wild-type extracts)

immune system

abnormal inflammatory response ( J:80114 )

• 72 hours following thioglycollate injection into the peritoneum, recruitment of leukocytes is severely compromised (9.34+/-0.43 x10⁶ leukocytes in the peritoneum compared to 28.7+/-1.62 x10⁶ in wild-type mice)