Phenotypes Associated with This Genotype

Genotype
MGI:3720651

• Allelic Composition: Ctnna1^tm1Efu/Ctnna1^tm1Efu; Tg(Wap-cre)11738Mam/?
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body weight ( J:87469 )

• pups with homozygous mothers weight 50% of normal mice

postnatal growth retardation ( J:87469 )

• pups with homozygous mothers fail to thrive

endocrine/exocrine glands

abnormal mammary gland epithelium morphology ( J:87469 )

♀ • mammary glands have reduced numbers of epithelial cells

♀ • some epithelial cells remain condensed and disorganized without forming alveolar structures

♀ • lumens are absent from clusters of epithelium

abnormal milk composition ( J:87469 )

♀ • milk proteins are reduced

increased mammary gland apoptosis ( J:87469 )

♀ • apoptosis in mammary epithelium is increased

integument

abnormal mammary gland epithelium morphology ( J:87469 )

♀ • mammary glands have reduced numbers of epithelial cells

♀ • some epithelial cells remain condensed and disorganized without forming alveolar structures

♀ • lumens are absent from clusters of epithelium

abnormal milk composition ( J:87469 )

♀ • milk proteins are reduced

increased mammary gland apoptosis ( J:87469 )

♀ • apoptosis in mammary epithelium is increased

cellular

maternal effect ( J:87469 )

• pups with homozygous mothers fail to thrive, are about 50% of normal weight and some do not survive lactation

• in litters that experience lethality, the litters are reduced to 50% at day 5 and 25% by day 10