Analysis Tools
mortality/aging
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• mutant mice die at birth due to defects in forebrain development
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nervous system
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• at birth, mutants exhibit lethal defects in forebrain development
• however, overall development of the inner ear and cochlea appeared normal
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hearing/vestibular/ear
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• at E18.5, IHCs and OHCs appear to be in direct contact with each other in some cochlear sections
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• at E18.5, mutant mice show a significant reduction in the size and number of pillar cells (PCs) relative to control mice
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• at E18.5, the distance between the lateral edge of the IHC and the medial edge of the first row OHC (a measure of the degree of PC development) is significantly decreased along the length of the cochlea
• at E18.5, PCs with weak or no lumenal projections are noted along the entire cochlear length with no region-specific variations
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• at E18.5, pillar cells are missing or underdeveloped
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• at E18.5, lumenal surface of the organ of Corti shows disruption of pillar cell growth and close approximation of IHCs to OHCs
• however, the overall structure of the epithelium and putative developing pillar cells are normal up to E15
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cellular
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• at E18.5, the distance between the lateral edge of the IHC and the medial edge of the first row OHC (a measure of the degree of PC development) is significantly decreased along the length of the cochlea
• at E18.5, PCs with weak or no lumenal projections are noted along the entire cochlear length with no region-specific variations
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