Phenotypes Associated with This Genotype

Genotype
MGI:3720351

• Allelic Composition: Pax5^tm1Mbu/Pax5^tm3Mbu; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased mature B cell number ( J:75504 )

• half of the mature B cells in the spleen are absent

• only a small number of mature B cells are lost upon short-term inactivation of Pax5

• polyinosine-polycystosine (pIpC)-treated mice lack IgD+B220^hi cells

hematopoietic system

decreased mature B cell number ( J:75504 )

• half of the mature B cells in the spleen are absent

• only a small number of mature B cells are lost upon short-term inactivation of Pax5

• polyinosine-polycystosine (pIpC)-treated mice lack IgD+B220^hi cells