Phenotypes Associated with This Genotype

Genotype
MGI:3720330

• Allelic Composition: Gata3^tm1.1Mbu/Gata3^tm1.1Mbu
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal humoral immune response ( J:123631 )

• following infection of mature CD4+ T cells with a retroviral cre, a Notch intracellular domain vector failed to initiate IL-4 production as it does in wild-type cells and instead produced more interferon-gamma compared to wild-type cells similarly treated

increased interferon-gamma secretion ( J:123631 )

• following infection of mature CD4+ T cells with a retroviral cre, a Notch intracellular domain vector induced the production of more interferon-gamma compared to wild-type cells similarly treated

decreased interleukin-4 secretion ( J:123631 )

• following infection of mature CD4+ T cells with a retroviral cre, a Notch intracellular domain vector failed to initiate IL-4 production as it does in wild-type cells