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Phenotypes Associated with This Genotype
Genotype
MGI:3720325
Allelic
Composition
Myctm2Fwa/Myctm2Fwa
Gt(ROSA)26Sortm1Sor/?
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background
involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (945 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Myctm2Fwa mutation (2 available); any Myc mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• the coronal suture adjacent to the frontal bone has a curvilinear appearance and fails to fuse at the midline
• at 6 weeks, the frontal bone is defective and mostly composed of a cartilaginous membrane
• at 6 weeks, malleal defects are observed
• however, the incus and stapes are morphologically normal
• at 6 weeks, the manubrium is smaller than normal
• at 6 weeks, the body of the malleus is smaller than normal

hearing/vestibular/ear
• at 6 weeks, malleal defects are observed
• however, the incus and stapes are morphologically normal
• at 6 weeks, the manubrium is smaller than normal
• at 6 weeks, the body of the malleus is smaller than normal

skeleton
• the coronal suture adjacent to the frontal bone has a curvilinear appearance and fails to fuse at the midline
• at 6 weeks, the frontal bone is defective and mostly composed of a cartilaginous membrane
• at 6 weeks, malleal defects are observed
• however, the incus and stapes are morphologically normal
• at 6 weeks, the manubrium is smaller than normal
• at 6 weeks, the body of the malleus is smaller than normal

growth/size/body

respiratory system


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
05/21/2024
MGI 6.23
The Jackson Laboratory