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Phenotypes Associated with This Genotype
Genotype
MGI:3720197
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Ptpn6tm1Rsky/Ptpn6tm1Rsky
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (61 available)
Ptpn6tm1Rsky mutation (1 available); any Ptpn6 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased granulocyte number ( J:123568 )
• at 7 to 11 months of age
decreased follicular B cell number ( J:123568 )
• fewer CD23+CD21+IgM+ follicular B cells are detected
decreased marginal zone B cell number ( J:123568 )
• fewer CD211hiIgMhiCD1dhi marginal zone B cells are detected
increased B cell number ( J:123568 )
• at 7 to 11 months of age
increased plasma cell number ( J:123568 )
• at 7 to 11 months of age
increased T cell number ( J:123568 )
• at 7 to 11 months of age
increased macrophage cell number ( J:123568 )
• at 7 to 11 months of age
enlarged spleen ( J:123568 )
• at 7 to 11 months of age
enlarged lymph nodes ( J:123568 )
• at 7 to 11 months of age
decreased B cell proliferation ( J:123568 )
• following stimulation by anti-IgM or anti-CD40 antibodies, B cell proliferation is reduced
• however, proliferation stimulated by LPS is normal
abnormal humoral immune response ( J:123568 )
• antibody-mediated response to NP-CG is not as strong ad in wild-type mice
• antibody-mediated response to NP-ficoll is severely impaired
increased susceptibility to systemic lupus erythematosus ( J:123568 )
• at 7 to 11 months of age, mice develop an autoimmune disease with features similar to systemic lupus erythematosus

hematopoietic system
decreased B cell proliferation ( J:123568 )
• following stimulation by anti-IgM or anti-CD40 antibodies, B cell proliferation is reduced
• however, proliferation stimulated by LPS is normal
enlarged spleen ( J:123568 )
• at 7 to 11 months of age
increased granulocyte number ( J:123568 )
• at 7 to 11 months of age
decreased follicular B cell number ( J:123568 )
• fewer CD23+CD21+IgM+ follicular B cells are detected
decreased marginal zone B cell number ( J:123568 )
• fewer CD211hiIgMhiCD1dhi marginal zone B cells are detected
increased B cell number ( J:123568 )
• at 7 to 11 months of age
increased plasma cell number ( J:123568 )
• at 7 to 11 months of age
increased T cell number ( J:123568 )
• at 7 to 11 months of age
increased macrophage cell number ( J:123568 )
• at 7 to 11 months of age

growth/size/body
enlarged spleen ( J:123568 )
• at 7 to 11 months of age

cellular
decreased B cell proliferation ( J:123568 )
• following stimulation by anti-IgM or anti-CD40 antibodies, B cell proliferation is reduced
• however, proliferation stimulated by LPS is normal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory