Mouse Genome Informatics
ht
    Hbab2(th)/Hba+
either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
hematopoietic system
• reduced mean cell volume despite increased red cell numbers
• red cells of irregular size and shape with pitted surfaces and blebs are seen
• increase in the percentage of red blood cells with flattened or doughnut shape (26%) compared to controls
• red cells are 75 - 80% the size of wild-type cells
• increase in the percentage of acanthocytes and red blood cells with teardrop shape (43.2%) compared to controls
• Background Sensitivity: white cell numbers are increased in mice crossed to C57BL mice but not in those crossed to SEC mice

immune system
• Background Sensitivity: white cell numbers are increased in mice crossed to C57BL mice but not in those crossed to SEC mice

Mouse Models of Human Disease
OMIM IDRef(s)
Alpha-Thalassemia 604131 J:123943