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Phenotypes Associated with This Genotype
Genotype
MGI:3720079
Allelic
Composition
Hbab2(th)/Hba+
Genetic
Background
either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab2(th) mutation (0 available); any Hba mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• reduced mean cell volume despite increased red cell numbers
• red cells of irregular size and shape with pitted surfaces and blebs are seen
• increase in the percentage of red blood cells with flattened or doughnut shape (26%) compared to controls
• red cells are 75 - 80% the size of wild-type cells
• increase in the percentage of acanthocytes and red blood cells with teardrop shape (43.2%) compared to controls
• Background Sensitivity: white cell numbers are increased in mice crossed to C57BL mice but not in those crossed to SEC mice

immune system
• Background Sensitivity: white cell numbers are increased in mice crossed to C57BL mice but not in those crossed to SEC mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
alpha thalassemia DOID:1099 OMIM:604131
J:123943


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory