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Phenotypes Associated with This Genotype
Genotype
MGI:3720079
Allelic
Composition
Hbab2(th)/Hba+
Genetic
Background
either: (involves: 101 * SEC) or (involves: 101 * C57BL * SEC)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbab2(th) mutation (0 available); any Hba mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• reduced mean cell volume despite increased red cell numbers
• red cells of irregular size and shape with pitted surfaces and blebs are seen
• increase in the percentage of red blood cells with flattened or doughnut shape (26%) compared to controls
• red cells are 75 - 80% the size of wild-type cells
• increase in the percentage of acanthocytes and red blood cells with teardrop shape (43.2%) compared to controls
• Background Sensitivity: white cell numbers are increased in mice crossed to C57BL mice but not in those crossed to SEC mice

immune system
• Background Sensitivity: white cell numbers are increased in mice crossed to C57BL mice but not in those crossed to SEC mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Alpha-Thalassemia 604131 J:123943


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory