Phenotypes for En1 Lhx1 Lhx5 MGI:3719690 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	En1^tm2(cre)Wrst/En1⁺ Lhx1^tm1Tmj/Lhx1^tm2.1Bhr Lhx5^tm1Lmgd/Lhx5^tm1Lmgd
Genetic Background	involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm2(cre)Wrst mutation (1 available); any En1 mutation (34 available)
Lhx1^tm1Tmj mutation (0 available); any Lhx1 mutation (21 available)
Lhx1^tm2.1Bhr mutation (0 available); any Lhx1 mutation (21 available)
Lhx5^tm1Lmgd mutation (0 available); any Lhx5 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased Purkinje cell number ( J:123471 )

• largely absent at E18.5

absent Purkinje cell layer ( J:123471 )

• layer is absent at E18.5

• however, the external granule cell layer appears normal

small cerebellum ( J:123471 )

• small at E18.5 compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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