Phenotypes Associated with This Genotype

Genotype
MGI:3719414

• Allelic Composition: Txnip^Hyplip1/Txnip^Hyplip1
• Genetic Background: HcB19/Dem-Txnip^Hyplip1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:112292 )

• 41% of mice develop hepatocellular carcinomas tumors when control mice have no tumors

• some hepatic tumors observed form in more than one lobe

• tumor incidence increases with age starting at 8 months and reach 66% incidence by 20 to 24 months of age

• tumors are multifocal, some are red and black in color indicating hemorrhaging, some display fibrosis, some are yellow in color indicating the presence of fat deposits, contain macrovesicular fat, and form regeneration nodules

• males exhibit a higher incidence of tumors than females

• however, no preneoplastic increase in proliferation is observed

homeostasis/metabolism

increased circulating cholesterol level ( J:47109 )

• total cholesterol levels are elevated 30% to 60% relative to controls

increased circulating VLDL cholesterol level ( J:47109 )

• the number of VLDL particles is increased

increased circulating triglyceride level ( J:47109 )

• plasma triglyceride levels are 10- to 30-fold higher than in control mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:112292 )

• 41% of mice develop hepatocellular carcinomas tumors when control mice have no tumors

• some hepatic tumors observed form in more than one lobe

• tumor incidence increases with age starting at 8 months and reach 66% incidence by 20 to 24 months of age

• tumors are multifocal, some are red and black in color indicating hemorrhaging, some display fibrosis, some are yellow in color indicating the presence of fat deposits, contain macrovesicular fat, and form regeneration nodules

• males exhibit a higher incidence of tumors than females

• however, no preneoplastic increase in proliferation is observed

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:112292