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Phenotypes Associated with This Genotype
Genotype
MGI:3719168
Allelic
Composition		 Bcl6btm2Dent/Bcl6btm2Dent
Rag1tm1Mom/Rag1tm1Mom
Genetic
Background		 involves: 129/Sv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl6btm2Dent mutation (0 available); any Bcl6b mutation (14 available)
Rag1tm1Mom mutation (56 available); any Rag1 mutation (132 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal blood cell morphology/development ( J:123621 )
• mice have decreased hematopoeitic progenitor cell (HPC) number and cycling in the spleen compared to in Bcl6btm2Dent homozygotes but levels are similar to those in wild-type mice
• mice have decreased HPC number and cycling in the bone marrow similar to in Bcl6btm2Dent homozygotes
decreased lymphocyte cell number ( J:123621 )
• mice lack mature lymphocytes

immune system
decreased lymphocyte cell number ( J:123621 )
• mice lack mature lymphocytes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory