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Phenotypes Associated with This Genotype
Genotype
MGI:3719104
Allelic
Composition		 Efnb1tm1Sor/Efnb1+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb1tm1Sor mutation (1 available); any Efnb1 mutation (15 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
cleft palate ( J:89008 )
• in 15% of mice
failure of palatal shelf elevation ( J:89008 )
• at E14.5, palatal shelves fail to elevate

hearing/vestibular/ear
abnormal tympanic ring morphology ( J:89008 )
• bilaterally defective

digestive/alimentary system
cleft palate ( J:89008 )
• in 15% of mice
failure of palatal shelf elevation ( J:89008 )
• at E14.5, palatal shelves fail to elevate

growth/size/body
cleft palate ( J:89008 )
• in 15% of mice
failure of palatal shelf elevation ( J:89008 )
• at E14.5, palatal shelves fail to elevate

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory