Phenotypes Associated with This Genotype

Genotype
MGI:3719019

• Allelic Composition: Tg(Col2a1-Mef2c/VP16)1Eno/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal neurocranium morphology ( J:119152 )

• cranial vault is deformed due to premature fusion of the endochondral growth plates

abnormal epiphyseal plate morphology ( J:119152 )

• growth plate maturation in the sternum and forearm is accelerated, where nearly all chondrocytes in the growth plate are consumed by premature differentiation

premature endochondral bone ossification ( J:119152 )

• premature endochondral ossification at E18.5

• growth plates separating the sternebrae are prematurely ossified, resulting in complete ossification along the length of the sternum

• entire vertebrae are ossified due to premature fusion of the growth plates between the vertebral body and the lateral vertebral processes

craniofacial

abnormal neurocranium morphology ( J:119152 )

• cranial vault is deformed due to premature fusion of the endochondral growth plates

limbs/digits/tail

abnormal forelimb morphology ( J:119152 )

• growth plate cartilages of the limbs are inappropriately ossified, resulting in distortion of the forelimb

short limbs ( J:119152 )