Phenotypes Associated with This Genotype

Genotype
MGI:3718798

• Allelic Composition: En1^tm1Alj/En1^tm1Alj
• Genetic Background: B6.129-En1^tm1Alj

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:84363 )

• born in normal numbers

• reduced vitality and frequently die before weaning

growth/size/body

decreased body size ( J:84363 )

• smaller than littermates within a few days of birth

nervous system

abnormal cerebellar lobule formation ( J:84363 )

• fusion of cerebellar lobules IV and V

• Background Sensitivity: otherwise phenotypically normal cerebellum is seen as early as the third backcross generation to C57BL/6 and thereafter

decreased inferior colliculus size ( J:84363 )

• mild truncation seen in the midbrain in the area of the inferior colliculi

limbs/digits/tail

abnormal autopod morphology ( J:84363 )

• fur growth on the ventral surface of the forepaws

abnormal digit morphology ( J:84363 )

• circumferential nails on all digits

polydactyly ( J:84363 )

• 6th postaxial digit

• ectopic digits

syndactyly ( J:84363 )

integument

deformed nails ( J:84363 )

• circumferential nails on all digits