Phenotypes Associated with This Genotype

Genotype
MGI:3718430

• Allelic Composition: Unc13a^tm2Bros/Unc13a⁺; Unc13b^tm2Bros/Unc13b^tm2Bros
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal synaptic vesicle morphology ( J:117827 )

• spontaneous release rates are intermediate and are increased by PDBu (4beta-phorbol-12,13-dibutyrate) treatment

abnormal synaptic vesicle number ( J:117827 )

• the number of fusion-competent vesicles is reduced to 2763+/-305 vesicles compared to 4109+/-722 vesicles in wild-type mice

abnormal excitatory postsynaptic currents ( J:117827 )

• at 10Hz action potential trains, excitatory postsynaptic current depression is enhanced relative to that in wild-type cells but not as much as in homozygotes and further enhanced by treatment with PDBu (4beta-phorbol-12,13-dibutyrate)

cellular

abnormal synaptic vesicle morphology ( J:117827 )

• spontaneous release rates are intermediate and are increased by PDBu (4beta-phorbol-12,13-dibutyrate) treatment

abnormal synaptic vesicle number ( J:117827 )

• the number of fusion-competent vesicles is reduced to 2763+/-305 vesicles compared to 4109+/-722 vesicles in wild-type mice