Unc13btm2Bros
Targeted Allele Detail
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Symbol: |
Unc13btm2Bros |
Name: |
unc-13 homolog B; targeted mutation 2, Nils Brose |
MGI ID: |
MGI:2449706 |
Synonyms: |
Munc13-2 KO, Unc13bKO, Unc13btm1Rmnd |
Gene: |
Unc13b Location: Chr4:43058953-43264871 bp, + strand Genetic Position: Chr4, 23.0 cM, cytoband B1
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Alliance: |
Unc13btm2Bros page
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Germline Transmission: |
Earliest citation of germline transmission:
J:77339
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The gene was disrupted by replacement of nucleotides 1439-2436 with a neomycin resistance gene via homologous recombination. Gene expression was completely absent in homozygous mutant animals as determined by Western blot analysis. An antibody recognizing all proteins isoforms was used for Western blotting.
(J:77339)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Unc13b Mutation: |
119 strains or lines available
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Original: |
J:77339 Varoqueaux F, et al., Total arrest of spontaneous and evoked synaptic transmission but normal synaptogenesis in the absence of Munc13-mediated vesicle priming. Proc Natl Acad Sci U S A. 2002 Jun 25;99(13):9037-42 |
All: |
40 reference(s) |
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