Analysis Tools
behavior/neurological
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• mice show no signs of hyperactivity
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• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt
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• in the hidden platform version of the Morris water maze, non-trangenic controls, regardless of Mapt genotype learn the task over 3 days, whereas transgenic mice heterozygous for Mapttm1Hnd show show impaired learning compared to controls but less impairment than transgenic mice with normal Mapt expression
• in probe trials where the platform is removed, mice show delayed learning, compared to non transgenic controls or transgenic mice with wild-type Mapt, with more target than non-target crossings after 5 days of training
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nervous system
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• seizures are less severe and occur at longer latencies compared to transgenic mice with wild-type Mapt
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• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics null or wild-type for Mapt
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• mice show neuritic dystrophy around amyloid plaques
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• aberrant sprouting of hippocampal axons is observed in transgenic mice
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cellular
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• aberrant sprouting of hippocampal axons is observed in transgenic mice
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homeostasis/metabolism
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• at 4-7 months and 14-18 months, Abeta plaque deposition is observed, at levels the same as other transgenics null or wild-type for Mapt
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