Phenotypes Associated with This Genotype

Genotype
MGI:3718220

• Allelic Composition: Enah^tm1Fbg/Enah^tm1Fbg
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:53259 )

• smaller than their wild-type or heterozygous littermates until adulthood

behavior/neurological

decreased locomotor activity ( J:53259 )

• reduced activity in home cage

nervous system

abnormal axon guidance ( J:53259 )

• fibers in the corpus callosum appeared to reach a point just medial to the cingulum bundle but failed to project medially and cross the midline

• most of the fibers formed dense neuromas

abnormal brain commissure morphology ( J:53259 )

• defects in midline fiber crossing in the pons

• no defects were observed in other commissures, including spinal motor neuron tracts, or in cortical lamination

absent corpus callosum ( J:53259 )

• observed in 11 out of 20 homozygous mutant mice but was never observed in 20 littermate control animals

• the defects is not from an effect of genetic background of 129sv strain

abnormal hippocampal commissure morphology ( J:53259 )

• fibers of the hippocampal commissure are abnormal

• instead of crossing contralaterally, they appeared to reach the midline and project ipsilaterally

• in more caudal sections hippocampal commissure fibers crossed the midline

cellular

abnormal axon guidance ( J:53259 )

• fibers in the corpus callosum appeared to reach a point just medial to the cingulum bundle but failed to project medially and cross the midline

• most of the fibers formed dense neuromas