About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3717921
Allelic
Composition		 Sox17tm1Sjm/Sox17tm2Sjm
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129/Sv * C3H * C57BL/6 * C57BL/Ka * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Sjm mutation (1 available); any Sox17 mutation (29 available)
Sox17tm2Sjm mutation (1 available); any Sox17 mutation (29 available)
Tg(Mx1-cre)1Cgn mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:123050 )
• death of all mice by 14 days after birth

hematopoietic system
thymus hypoplasia ( J:123050 )
• mice display severe reduction in thymus cellularity upon examination at 4-5 days after end of poly(I:C) treatment
decreased bone marrow cell number ( J:123050 )
• when sacrificed 4-5 days after end of poly(I:C) treatment, reduced bone marrow cellularity is observed
thrombocytopenia ( J:123050 )
• numbers are significantly reduce compared to controls following cre induction
decreased leukocyte cell number ( J:123050 )
• numbers are significantly reduce compared to controls following cre induction
decreased hematopoietic stem cell number ( J:123050 )
• HSCs are reduced in bone marrow and spleen
spleen hypoplasia ( J:123050 )
• when sacrificed 4-5 days after end of poly(I:C) treatment, reduced spleen cellularity is observed

immune system
thymus hypoplasia ( J:123050 )
• mice display severe reduction in thymus cellularity upon examination at 4-5 days after end of poly(I:C) treatment
decreased leukocyte cell number ( J:123050 )
• numbers are significantly reduce compared to controls following cre induction
spleen hypoplasia ( J:123050 )
• when sacrificed 4-5 days after end of poly(I:C) treatment, reduced spleen cellularity is observed

endocrine/exocrine glands
thymus hypoplasia ( J:123050 )
• mice display severe reduction in thymus cellularity upon examination at 4-5 days after end of poly(I:C) treatment

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory