Phenotypes Associated with This Genotype

Genotype
MGI:3717921

• Allelic Composition: Sox17^tm1Sjm/Sox17^tm2Sjm; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129/Sv * C3H * C57BL/6 * C57BL/Ka * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:123050 )

• death of all mice by 14 days after birth

hematopoietic system

thymus hypoplasia ( J:123050 )

• mice display severe reduction in thymus cellularity upon examination at 4-5 days after end of poly(I:C) treatment

decreased bone marrow cell number ( J:123050 )

• when sacrificed 4-5 days after end of poly(I:C) treatment, reduced bone marrow cellularity is observed

thrombocytopenia ( J:123050 )

• numbers are significantly reduce compared to controls following cre induction

decreased leukocyte cell number ( J:123050 )

• numbers are significantly reduce compared to controls following cre induction

decreased hematopoietic stem cell number ( J:123050 )

• HSCs are reduced in bone marrow and spleen

spleen hypoplasia ( J:123050 )

• when sacrificed 4-5 days after end of poly(I:C) treatment, reduced spleen cellularity is observed

immune system

thymus hypoplasia ( J:123050 )

• mice display severe reduction in thymus cellularity upon examination at 4-5 days after end of poly(I:C) treatment

decreased leukocyte cell number ( J:123050 )

• numbers are significantly reduce compared to controls following cre induction

spleen hypoplasia ( J:123050 )

• when sacrificed 4-5 days after end of poly(I:C) treatment, reduced spleen cellularity is observed

endocrine/exocrine glands

thymus hypoplasia ( J:123050 )

• mice display severe reduction in thymus cellularity upon examination at 4-5 days after end of poly(I:C) treatment