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Phenotypes Associated with This Genotype
Genotype
MGI:3717920
Allelic
Composition		 Sox17tm1Sjm/Sox17tm2Sjm
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * C57BL/Ka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Sjm mutation (1 available); any Sox17 mutation (28 available)
Sox17tm2Sjm mutation (1 available); any Sox17 mutation (28 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:123050 )
• expected numbers of homozygotes are found at E12.5, but complete lethality is observed by E13.5

embryo
embryonic growth retardation ( J:123050 )
• at E12.5, mutants are growth retarded
abnormal embryonic hematopoiesis ( J:123050 )
• no hematopoiesis is visible in the yolk sac or embryo at E12.5

growth/size/body
embryonic growth retardation ( J:123050 )
• at E12.5, mutants are growth retarded

hematopoietic system
abnormal embryonic hematopoiesis ( J:123050 )
• no hematopoiesis is visible in the yolk sac or embryo at E12.5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory