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Phenotypes Associated with This Genotype
Genotype
MGI:3717771
Allelic
Composition		 Itgb6tm1Des/Itgb6tm1Des
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itgb6tm1Des mutation (0 available); any Itgb6 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Abnormal vascular development in Tgfb1tm1Jmu/Tgfb1tm1Jmu mice and fewer Langerhans cells in Tgfb1tm1Jmu/Tgfb1tm1Jmu and Itgb6tm1Des/Itgb6tm1Des mice

immune system
decreased Langerhans cell number ( J:120085 )
• Langerhans cells are less abundant in back epidermis
absent Langerhans cell ( J:120085 )
• Langerhans cells are absent from ear epidermis
abnormal immune system physiology ( J:120085 )
• mild inflammation occurs in the lung and skin

hematopoietic system
decreased Langerhans cell number ( J:120085 )
• Langerhans cells are less abundant in back epidermis
absent Langerhans cell ( J:120085 )
• Langerhans cells are absent from ear epidermis

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory