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Phenotypes Associated with This Genotype
Genotype
MGI:3717712
Allelic
Composition		 Tg(Gfap-TGFB1)64Lms/0
Tg(PDGFB-APPInd)H6Lms/0
Genetic
Background		 involves: BALB/c * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Gfap-TGFB1)64Lms mutation (1 available)
Tg(PDGFB-APPInd)H6Lms mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
cerebral amyloid angiopathy ( J:102272 )
• double transgenic mice display cerebrovascular deposits by 2-3 months of age, while single transgenic littermates have no such deposits at that age

homeostasis/metabolism
amyloidosis ( J:102272 )
• double transgenic mice display cerebrovascular and meningeal amyloid deposits by 2-3 months of age, while single transgenic littermates have no such deposits at that age
cerebral amyloid angiopathy ( J:102272 )
• double transgenic mice display cerebrovascular deposits by 2-3 months of age, while single transgenic littermates have no such deposits at that age

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory