Phenotypes Associated with This Genotype

Genotype
MGI:3717708

• Allelic Composition: Tg(Gfap-TGFB1)64Lms/0
• Genetic Background: involves: BALB/c * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

astrocytosis ( J:27781 )

• mice show characteristic pattern of perivascular astrocytosis, that is less intense than in homozygotes

abnormal astrocyte physiology ( J:27781 )

• astrocytes secrete increased amounts of bioactive TGF-B1

cerebral amyloid angiopathy ( J:102272 )

• in 12-18 month old mice, prominent amyloid deposits are observed in cerebral blood vessels, whereas none are seen in controls

hydrocephaly ( J:27781 )

• hydroencephaly was observed in only 1% (1/101) of hemizygous mice

abnormal meninges morphology ( J:27781 )

• meningeal coverings are thicker than controls

immune system

immune system phenotype ( J:27781 )

N • no inflammatory cell infiltrates are seen in hemizygous or control mice

homeostasis/metabolism

amyloidosis ( J:102272 )

• in 12-18 month old mice, prominent amyloid deposits are observed in meninges, whereas none are seen in controls

cerebral amyloid angiopathy ( J:102272 )

• in 12-18 month old mice, prominent amyloid deposits are observed in cerebral blood vessels, whereas none are seen in controls

cellular

astrocytosis ( J:27781 )

• mice show characteristic pattern of perivascular astrocytosis, that is less intense than in homozygotes

abnormal astrocyte physiology ( J:27781 )

• astrocytes secrete increased amounts of bioactive TGF-B1