Phenotypes Associated with This Genotype

Genotype
MGI:3717707

• Allelic Composition: Tg(Gfap-TGFB1)64Lms/Tg(Gfap-TGFB1)64Lms
• Genetic Background: involves: BALB/c * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased body size ( J:27781 )

• at 23 days of age, animals are dwarfs with reduced body weights (6.7 grams) compared to heterozygous or non-transgenic littermates (11.1 grams)

behavior/neurological

tremors ( J:27781 )

• hydroencephaly is accompanied by development of tremors

impaired coordination ( J:27781 )

• hydroencephaly is accompanied by lack of coordination

hunched posture ( J:27781 )

• hydroencephaly is accompanied by hunched posture

seizures ( J:27781 )

• hydroencephaly is accompanied by development of seizures

nervous system

seizures ( J:27781 )

• hydroencephaly is accompanied by development of seizures

hydrocephaly ( J:27781 )

• between 7 and 20 days after birth, all mice develop hydroencephaly

abnormal brain ventricle morphology ( J:27781 )

• lateral, third, and fourth ventricles are grossly enlarged; ependymal canal is severely enlarged

• foramina through which cerebrospinal fluid circulates remain open

enlarged fourth ventricle ( J:27781 )

enlarged lateral ventricles ( J:27781 )

enlarged third ventricle ( J:27781 )

enlarged cerebral aqueduct ( J:27781 )

• sylvian canal is enlarged

brain atrophy ( J:27781 )

• brain regions adjacent to dilated cerebrospinal fluid spaces exhibit atrophy by compression

astrocytosis ( J:27781 )

• mice show characteristic pattern of perivascular astrocytosis

abnormal meninges morphology ( J:27781 )

• meningeal coverings are thicker than in hemizygotes or controls

immune system

immune system phenotype ( J:27781 )

N • no inflammatory cell infiltrates are seen in control mice or in transgenic mice displaying hydroencephaly