Phenotypes Associated with This Genotype

Genotype
MGI:3717463

• Allelic Composition: Jag1^Mhdahtu/Jag1^Mhdahtu
• Genetic Background: C3HeB/FeJ-Jag1^Mhdahtu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Jag1^Mhdahtu/Jag1^Mhdahtu mice die because of defects in vascular remodeling

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:72108 )

• die around E11.5

growth/size/body

embryonic growth retardation ( J:72108 )

• almost all E11.5 embryos appear to be delayed in development by a day or half a day

embryo

abnormal vitelline vasculature morphology ( J:72108 )

• absence or great reduction in the number of large blood vessels in the yolk sacs

embryonic growth retardation ( J:72108 )

• almost all E11.5 embryos appear to be delayed in development by a day or half a day

kinked neural tube ( J:72108 )

• some embryos exhibit a kinky neural tube

cardiovascular system

abnormal blood vessel morphology ( J:72108 )

• less branching of vessels in the head region

abnormal vitelline vasculature morphology ( J:72108 )

• absence or great reduction in the number of large blood vessels in the yolk sacs

enlarged pericardium ( J:72108 )

• some embryos exhibit an expanded pericardium

hemorrhage ( J:72108 )

• hemorrhage

nervous system

kinked neural tube ( J:72108 )

• some embryos exhibit a kinky neural tube