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Phenotypes Associated with This Genotype
Genotype
MGI:3717275
Allelic
Composition		 Grb2tm1Paw/Grb2+
Ptentm2Mak/Ptentm2Mak
Tg(Lck-cre)548Jxm/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2tm1Paw mutation (0 available); any Grb2 mutation (45 available)
Ptentm2Mak mutation (4 available); any Pten mutation (86 available)
Tg(Lck-cre)548Jxm mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased T cell derived lymphoma incidence ( J:93530 )
• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:93530 )
• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

immune system
increased T cell derived lymphoma incidence ( J:93530 )
• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

hematopoietic system
increased T cell derived lymphoma incidence ( J:93530 )
• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory